› 1ovz

X-ray diffraction
3Å resolution

Crystal structure of human FcaRI

Released:
DOI: 10.2210/pdb1ovz/pdb
PDB entry 1ovz coloured by chain, front view.
PDB entry 1ovz coloured by chain, side view.
PDB entry 1ovz coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Insights into IgA-mediated immune responses from the crystal structures of human FcalphaRI and its complex with IgA1-Fc.
Herr AB, Ballister ER, Bjorkman PJ
Nature 423 614-20 (2003)
PMID: 12768205

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-150154 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Immunoglobulin alpha Fc receptor Chains: A, B
Molecule details ›
Chains: A, B
Length: 207 amino acids
Theoretical weight: 23.62 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P24071 (Residues: 22-216; Coverage: 73%)
Gene names: CD89, FCAR
Sequence domains: Immunoglobulin domain
Structure domains: Immunoglobulins

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
2 bound ligands:
Ligand NAG 3 x NAG
Ligand TRS 1 x TRS
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL9-2
Spacegroup: I41
Unit cell:
a: 158.15Å b: 158.15Å c: 39.91Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.235 0.235 0.292
Expression system: Trichoplusia ni

Quick links

Citations

49 review citations

The function of immunoglobulin A in immunity.
Woof et al. (2006)
48 more

1 mention without citation

Identification of therapeutic targets for inflammation in sickle cell disease (SCD) among Indian patients using gene expression data analysis.
Das et al. (2018)