› 1oz2

X-ray diffraction
1.55Å resolution

CRYSTAL STRUCTURE OF 3-MBT REPEATS OF LETHAL (3) MALIGNANT BRAIN TUMOR (NATIVE-II) AT 1.55 ANGSTROM

Released:
DOI: 10.2210/pdb1oz2/pdb
PDB entry 1oz2 coloured by chain, front view.
PDB entry 1oz2 coloured by chain, side view.
PDB entry 1oz2 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Malignant brain tumor repeats: a three-leaved propeller architecture with ligand/peptide binding pockets.
Wang WK, Tereshko V, Boccuni P, MacGrogan D, Nimer SD, Patel DJ
Structure 11 775-89 (2003)
PMID: 12842041

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-195224 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Lethal(3)malignant brain tumor-like protein 1 Chain: A
Molecule details ›
Chain: A
Length: 331 amino acids
Theoretical weight: 37.81 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9Y468 (Residues: 265-595; Coverage: 39%)
Gene names: KIAA0681, L3MBT, L3MBTL, L3MBTL1
Sequence domains: mbt repeat
Structure domains: SH3 type barrels.

Ligands and Environments

2 bound ligands:
Ligand SO4 4 x SO4
Ligand MES 4 x MES
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P21212
Unit cell:
a: 86.68Å b: 93.403Å c: 58.578Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.19 0.189 0.218
Expression system: Escherichia coli

Quick links

Citations

9 review citations

How chromatin-binding modules interpret histone modifications: lessons from professional pocket pickers.
Taverna et al. (2007)
8 more

4 mentions without citation

MBT domain proteins in development and disease.
Bonasio et al. (2010)
3 more