› 1p4o

X-ray diffraction
1.5Å resolution

Structure of Apo unactivated IGF-1R KInase domain at 1.5A resolution.

Released:
DOI: 10.2210/pdb1p4o/pdb
PDB entry 1p4o coloured by chain, front view.
PDB entry 1p4o coloured by chain, side view.
PDB entry 1p4o coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of apo, unactivated insulin-like growth factor-1 receptor kinase at 1.5 A resolution.
Munshi S, Hall DL, Kornienko M, Darke PL, Kuo LC
Acta Crystallogr D Biol Crystallogr 59 1725-30 (2003)
PMID: 14501110

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-139909 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Insulin-like growth factor 1 receptor beta chain Chains: A, B
Molecule details ›
Chains: A, B
Length: 322 amino acids
Theoretical weight: 36.66 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P08069 (Residues: 973-1294; Coverage: 24%)
Gene name: IGF1R
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: P21
Unit cell:
a: 52.95Å b: 85.56Å c: 78.88Å
α: 90° β: 99.1° γ: 90°
R-values:
R R work R free
0.209 0.209 0.236
Expression system: Spodoptera frugiperda

Quick links

Citations

11 review citations

Regulation of protein kinases; controlling activity through activation segment conformation.
Nolen et al. (2004)
10 more

11 mentions without citation

How IGF-1 activates its receptor.
Kavran et al. (2014)
10 more