› 1p6s

Solution NMR

Solution Structure of the Pleckstrin Homology Domain of Human Protein Kinase B beta (Pkb/Akt)

Released:
DOI: 10.2210/pdb1p6s/pdb
PDB entry 1p6s coloured by chain, ensemble of 20 models, front view.
PDB entry 1p6s coloured by chain, ensemble of 20 models, side view.
PDB entry 1p6s coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Solution structure and backbone dynamics of the pleckstrin homology domain of the human protein kinase B (PKB/Akt). Interaction with inositol phosphates.
Auguin D, Barthe P, Augé-Sénégas MT, Stern MH, Noguchi M, Roumestand C
J Biomol NMR 28 137-55 (2004)
PMID: 14755158

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-152087 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
RAC-beta serine/threonine-protein kinase Chain: A
Molecule details ›
Chain: A
Length: 111 amino acids
Theoretical weight: 13.23 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P31751 (Residues: 1-111; Coverage: 23%)
Gene name: AKT2
Sequence domains: PH domain
Structure domains: Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: distance geometry, simulated annealing
Expression system: Escherichia coli BL21

Quick links

Citations

6 review citations

AKT crystal structure and AKT-specific inhibitors.
Kumar et al. (2005)
5 more

6 mentions without citation

Computer-Aided Identification of Kinase-Targeted Small Molecules for Cancer: A Review on AKT Protein.
Primavera et al. (2023)
5 more