1p7h

X-ray diffraction
2.6Å resolution

Structure of NFAT1 bound as a dimer to the HIV-1 LTR kB element

Released:
Source organism: Homo sapiens

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
PDBe Complex ID:
PDB-CPX-114365 (preferred)
Entry contents:
1 distinct polypeptide molecule
2 distinct DNA molecules
Macromolecules (3 distinct):
Nuclear factor of activated T-cells, cytoplasmic 2 Chains: L, M, N, O
Molecule details ›
Chains: L, M, N, O
Length: 286 amino acids
Theoretical weight: 32.49 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q13469 (Residues: 393-678; Coverage: 31%)
Gene names: NFAT1, NFATC2, NFATP
Sequence domains:
Structure domains:
5'-D(*AP*AP*TP*GP*GP*GP*GP*AP*CP*TP*TP*TP*CP*CP*A)-3' Chains: A, C
Molecule details ›
Chains: A, C
Length: 15 nucleotides
Theoretical weight: 4.61 KDa
Source organism: Homo sapiens
Expression system: Not provided
5'-D(*TP*TP*TP*GP*GP*AP*AP*AP*GP*TP*CP*CP*CP*CP*A)-3' Chains: B, D
Molecule details ›
Chains: B, D
Length: 15 nucleotides
Theoretical weight: 4.57 KDa
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 14-BM-C
Spacegroup: P1
Unit cell:
a: 74.107Å b: 80.321Å c: 80.308Å
α: 71.2° β: 78.97° γ: 78.94°
R-values:
R R work R free
0.265 0.231 0.265
Expression system: Not provided