Function and Biology Details
Reaction catalysed:
Release of mature proteins from their proproteins by cleavage of -Arg-Xaa-Yaa-Arg-|- bonds, where Xaa can be any amino acid and Yaa is Arg or Lys. Releases albumin, complement component C3 and von Willebrand factor from their respective precursors.
Biochemical function:
Biological process:
Cellular component:
- not assigned
Sequence domains:
Structure domains:
Structure analysis Details
Assemblies composition:
Assembly name:
Furin and peptide (preferred)
PDBe Complex ID:
PDB-CPX-149887 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (4 distinct):
Furin
Molecule details ›
Chains: A, B, C, D, E, F, G, H
Length: 471 amino acids
Theoretical weight: 51.15 KDa
Source organism: Mus musculus
Expression system: Cricetulus griseus
UniProt:
Sequence domains:
Structure domains:
Length: 471 amino acids
Theoretical weight: 51.15 KDa
Source organism: Mus musculus
Expression system: Cricetulus griseus
UniProt:
- Canonical:
P23188 (Residues: 108-578; Coverage: 61%)
Sequence domains:
Structure domains:
Ligands and Environments
No modified residues
Experiments and Validation Details
X-ray source:
MPG/DESY, HAMBURG BEAMLINE BW6
Spacegroup:
P1
Expression systems:
- Cricetulus griseus
- Not provided
