› 1p9a

X-ray diffraction
1.7Å resolution

Crystal Structure of N-Terminal Domain of Human Platelet Receptor Glycoprotein Ib-alpha at 1.7 Angstrom Resolution

Released:
DOI: 10.2210/pdb1p9a/pdb
PDB entry 1p9a coloured by chain, front view.
PDB entry 1p9a coloured by chain, side view.
PDB entry 1p9a coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Modulation of alpha-thrombin function by distinct interactions with platelet glycoprotein Ibalpha.
Celikel R, McClintock RA, Roberts JR, Mendolicchio GL, Ware J, Varughese KI, Ruggeri ZM
Science 301 218-21 (2003)
PMID: 12855810

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-139560 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Glycocalicin Chain: G
Molecule details ›
Chain: G
Length: 290 amino acids
Theoretical weight: 32.31 KDa
Source organism: Homo sapiens
Expression system: Drosophila melanogaster
UniProt:
  • Canonical: P07359 (Residues: 17-306; Coverage: 46%)
Gene name: GP1BA
Sequence domains:
Structure domains: Ribonuclease Inhibitor

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA
Carbohydrate polymer
No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL11-1
Spacegroup: P43
Unit cell:
a: 51.734Å b: 51.734Å c: 114.041Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.205 0.204 0.224
Expression system: Drosophila melanogaster

Quick links

Citations

38 review citations

Protease-activated receptors in hemostasis, thrombosis and vascular biology.
Coughlin SR. (2005)
37 more

15 mentions without citation

Surfing the Protein-Protein Interaction Surface Using Docking Methods: Application to the Design of PPI Inhibitors.
Sable et al. (2015)
14 more