› 1pb5

Solution NMR

NMR Structure of a Prototype LNR Module from Human Notch1

Released:
DOI: 10.2210/pdb1pb5/pdb
PDB entry 1pb5 coloured by chain, ensemble of 16 models, front view.
PDB entry 1pb5 coloured by chain, ensemble of 16 models, side view.
PDB entry 1pb5 coloured by chain, ensemble of 16 models, top view.
Source organism: Homo sapiens
Primary publication:
Nuclear magnetic resonance structure of a prototype Lin12-Notch repeat module from human Notch1.
Vardar D, North CL, Sanchez-Irizarry C, Aster JC, Blacklow SC
Biochemistry 42 7061-7 (2003)
PMID: 12795601

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-155479 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Neurogenic locus notch homolog protein 1 Chain: A
Molecule details ›
Chain: A
Length: 35 amino acids
Theoretical weight: 3.72 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P46531 (Residues: 1446-1480; Coverage: 1%)
Gene names: NOTCH1, TAN1
Sequence domains: LNR domain

Ligands and Environments

1 bound ligand:
Ligand CA 1 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: distance geometry, torsion angle dynamics, simulated annealing
Expression system: Escherichia coli

Quick links

Citations

5 review citations

Anchoring notch genetics and biochemistry; structural analysis of the ankyrin domain sheds light on existing data.
Lubman et al. (2004)
4 more

4 mentions without citation

The molecular logic of Notch signaling--a structural and biochemical perspective.
Gordon et al. (2008)
3 more