› 1pbw

X-ray diffraction
2Å resolution

STRUCTURE OF BCR-HOMOLOGY (BH) DOMAIN

Released:
DOI: 10.2210/pdb1pbw/pdb
PDB entry 1pbw coloured by chain, front view.
PDB entry 1pbw coloured by chain, side view.
PDB entry 1pbw coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of the breakpoint cluster region-homology domain from phosphoinositide 3-kinase p85 alpha subunit.
Musacchio A, Cantley LC, Harrison SC
Proc Natl Acad Sci U S A 93 14373-8 (1996)
PMID: 8962058

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-151131 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Phosphatidylinositol 3-kinase regulatory subunit alpha Chains: A, B
Molecule details ›
Chains: A, B
Length: 216 amino acids
Theoretical weight: 24.3 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P27986 (Residues: 105-319; Coverage: 30%)
Gene names: GRB1, PIK3R1
Sequence domains: RhoGAP domain
Structure domains: Rho GTPase activation protein

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P21
Unit cell:
a: 39.051Å b: 90.513Å c: 69.28Å
α: 90° β: 97.19° γ: 90°
R-values:
R R work R free
0.184 0.184 0.235
Expression system: Escherichia coli

Quick links

Citations

20 review citations

Phosphoinositide kinases.
Fruman et al. (1998)
19 more

18 mentions without citation

Somatic mutations in PI3Kalpha: structural basis for enzyme activation and drug design.
Gabelli et al. (2010)
17 more