› 1pht

X-ray diffraction
2Å resolution

PHOSPHATIDYLINOSITOL 3-KINASE P85-ALPHA SUBUNIT SH3 DOMAIN, RESIDUES 1-85

Released:
DOI: 10.2210/pdb1pht/pdb
PDB entry 1pht coloured by chain, front view.
PDB entry 1pht coloured by chain, side view.
PDB entry 1pht coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of P13K SH3 domain at 20 angstroms resolution.
Liang J, Chen JK, Schreiber ST, Clardy J
J Mol Biol 257 632-43 (1996)
PMID: 8648629

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-151131 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Phosphatidylinositol 3-kinase regulatory subunit alpha Chain: A
Molecule details ›
Chain: A
Length: 85 amino acids
Theoretical weight: 9.63 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P27986 (Residues: 1-85; Coverage: 12%)
Gene names: GRB1, PIK3R1
Structure domains: SH3 Domains

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P43212
Unit cell:
a: 47Å b: 47Å c: 92.3Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.223 0.223 0.258
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

7 review citations

Structure and function of phosphoinositide 3-kinases.
Wymann et al. (1998)
6 more

15 mentions without citation

Native protein sequences are close to optimal for their structures.
Kuhlman et al. (2000)
14 more