› 1pi1

X-ray diffraction
2Å resolution

Crystal structure of a human Mob1 protein; toward understanding Mob-regulated cell cycle pathways.

Released:
DOI: 10.2210/pdb1pi1/pdb
PDB entry 1pi1 coloured by chain, front view.
PDB entry 1pi1 coloured by chain, side view.
PDB entry 1pi1 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of a human Mob1 protein: toward understanding Mob-regulated cell cycle pathways.
Stavridi ES, Harris KG, Huyen Y, Bothos J, Verwoerd PM, Stayrook SE, Pavletich NP, Jeffrey PD, Luca FC
Structure 11 1163-70 (2003)
PMID: 12962634

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-190680 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
MOB kinase activator 1A Chain: A
Molecule details ›
Chain: A
Length: 185 amino acids
Theoretical weight: 21.53 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q9H8S9 (Residues: 33-216; Coverage: 85%)
Gene names: C2orf6, MOB1A, MOB4B, MOBK1B, MOBKL1B
Sequence domains: Mob1/phocein family
Structure domains: MOB kinase activator

Ligands and Environments

1 bound ligand:
Ligand ZN 1 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X9A
Spacegroup: P3221
Unit cell:
a: 67.676Å b: 67.676Å c: 95.595Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.207 0.205 0.242
Expression system: Escherichia coli BL21

Quick links

Citations

12 review citations

Hippo signaling: growth control and beyond.
Halder et al. (2011)
11 more

6 mentions without citation

Structural basis for Mob1-dependent activation of the core Mst-Lats kinase cascade in Hippo signaling.
Ni et al. (2015)
5 more