› 1pk2

Solution NMR

SOLUTION STRUCTURE OF THE TISSUE-TYPE PLASMINOGEN ACTIVATOR KRINGLE 2 DOMAIN COMPLEXED TO 6-AMINOHEXANOIC ACID AN ANTIFIBRINOLYTIC DRUG

Released:
DOI: 10.2210/pdb1pk2/pdb
PDB entry 1pk2 coloured by chain, front view.
PDB entry 1pk2 coloured by chain, side view.
PDB entry 1pk2 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Solution structure of the tissue-type plasminogen activator kringle 2 domain complexed to 6-aminohexanoic acid an antifibrinolytic drug.
Byeon IJ, Llinás M
J Mol Biol 222 1035-51 (1991)
PMID: 1762144

Function and Biology Details

Reaction catalysed: 
Specific cleavage of Arg-|-Val bond in plasminogen to form plasmin.
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-133299 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tissue-type plasminogen activator chain A Chain: A
Molecule details ›
Chain: A
Length: 90 amino acids
Theoretical weight: 9.87 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P00750 (Residues: 209-298; Coverage: 17%)
Gene name: PLAT
Sequence domains: Kringle domain
Structure domains: Plasminogen Kringle 4

Ligands and Environments

1 bound ligand:
Ligand ACA 1 x ACA
No modified residues

Experiments and Validation Details

Entry percentile scores
Expression system: Not provided

Quick links

Citations

6 review citations

The plasmin-antiplasmin system: structural and functional aspects.
Schaller et al. (2011)
5 more

4 mentions without citation

Blood-brain barrier permeability and tPA-mediated neurotoxicity.
Abu Fanne et al. (2010)
3 more