› 1pk5

X-ray diffraction
2.4Å resolution

Crystal structure of the orphan nuclear receptor LRH-1

Released:
DOI: 10.2210/pdb1pk5/pdb
PDB entry 1pk5 coloured by chain, front view.
PDB entry 1pk5 coloured by chain, side view.
PDB entry 1pk5 coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Structural basis for ligand-independent activation of the orphan nuclear receptor LRH-1.
Sablin EP, Krylova IN, Fletterick RJ, Ingraham HA
Mol Cell 11 1575-85 (2003)
PMID: 12820970

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-155283 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Nuclear receptor subfamily 5 group A member 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 248 amino acids
Theoretical weight: 28.73 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: P45448 (Residues: 313-560; Coverage: 44%)
Gene names: Lrh1, Nr5a2
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.3.1
Spacegroup: P21
Unit cell:
a: 34.775Å b: 127.542Å c: 53.213Å
α: 90° β: 91.72° γ: 90°
R-values:
R R work R free
0.215 0.208 0.235
Expression system: Escherichia coli

Quick links

Citations

36 review citations

Overview of nomenclature of nuclear receptors.
Germain et al. (2006)
35 more

7 mentions without citation

The crystal structures of human steroidogenic factor-1 and liver receptor homologue-1.
Wang et al. (2005)
6 more