› 1pnj

Solution NMR

SOLUTION STRUCTURE AND LIGAND-BINDING SITE OF THE SH3 DOMAIN OF THE P85ALPHA SUBUNIT OF PHOSPHATIDYLINOSITOL 3-KINASE

Released:
DOI: 10.2210/pdb1pnj/pdb
PDB entry 1pnj coloured by chain, front view.
PDB entry 1pnj coloured by chain, side view.
PDB entry 1pnj coloured by chain, top view.
Source organism: Bos taurus
Primary publication:
Solution structure and ligand-binding site of the SH3 domain of the p85 alpha subunit of phosphatidylinositol 3-kinase.
Booker GW, Gout I, Downing AK, Driscoll PC, Boyd J, Waterfield MD, Campbell ID
Cell 73 813-22 (1993)
PMID: 7684655

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-150051 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Phosphatidylinositol 3-kinase regulatory subunit alpha Chain: A
Molecule details ›
Chain: A
Length: 86 amino acids
Theoretical weight: 9.65 KDa
Source organism: Bos taurus
Expression system: Not provided
UniProt:
  • Canonical: P23727 (Residues: 1-84; Coverage: 12%)
Gene name: PIK3R1
Structure domains: SH3 Domains

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Expression system: Not provided

Quick links

Citations

24 review citations

Phosphoinositide kinases.
Fruman et al. (1998)
23 more

6 mentions without citation

Somatic mutations in PI3Kalpha: structural basis for enzyme activation and drug design.
Gabelli et al. (2010)
5 more