› 1pq9

X-ray diffraction
2.1Å resolution

HUMAN LXR BETA HORMONE RECEPTOR COMPLEXED WITH T0901317 COMPLEX

Released:
DOI: 10.2210/pdb1pq9/pdb
PDB entry 1pq9 coloured by chain, front view.
PDB entry 1pq9 coloured by chain, side view.
PDB entry 1pq9 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The three-dimensional structure of the liver X receptor beta reveals a flexible ligand-binding pocket that can accommodate fundamentally different ligands.
Färnegårdh M, Bonn T, Sun S, Ljunggren J, Ahola H, Wilhelmsson A, Gustafsson JA, Carlquist M
J Biol Chem 278 38821-8 (2003)
PMID: 12819202

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assemblies composition:
homo dimer (preferred)
homo tetramer
Assembly name:
PDBe Complex ID:
PDB-CPX-157162 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Oxysterols receptor LXR-beta Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 253 amino acids
Theoretical weight: 29.06 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P55055 (Residues: 212-460; Coverage: 54%)
Gene names: LXRB, NER, NR1H2, UNR
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

2 bound ligands:
Ligand BNS 4 x BNS
Ligand 44B 4 x 44B
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-4
Spacegroup: P212121
Unit cell:
a: 58.866Å b: 103.606Å c: 176.378Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.216 0.214 0.254
Expression system: Escherichia coli

Quick links

Citations

14 review citations

Principles for modulation of the nuclear receptor superfamily.
Gronemeyer et al. (2004)
13 more

5 mentions without citation

Dendrogenin A drives LXR to trigger lethal autophagy in cancers.
Segala et al. (2017)
4 more