› 1pqc

X-ray diffraction
2.8Å resolution

HUMAN LXR BETA HORMONE RECEPTOR COMPLEXED WITH T0901317

Released:
DOI: 10.2210/pdb1pqc/pdb
PDB entry 1pqc coloured by chain, front view.
PDB entry 1pqc coloured by chain, side view.
PDB entry 1pqc coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The three-dimensional structure of the liver X receptor beta reveals a flexible ligand-binding pocket that can accommodate fundamentally different ligands.
Färnegårdh M, Bonn T, Sun S, Ljunggren J, Ahola H, Wilhelmsson A, Gustafsson JA, Carlquist M
J Biol Chem 278 38821-8 (2003)
PMID: 12819202

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assemblies composition:
homo dimer (preferred)
homo tetramer
Assembly name:
PDBe Complex ID:
PDB-CPX-157162 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Oxysterols receptor LXR-beta Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 253 amino acids
Theoretical weight: 29.06 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P55055 (Residues: 212-460; Coverage: 54%)
Gene names: LXRB, NER, NR1H2, UNR
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

1 bound ligand:
Ligand 444 4 x 444
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU300
Spacegroup: P212121
Unit cell:
a: 58.722Å b: 103.262Å c: 176.002Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.199 0.195 0.262
Expression system: Escherichia coli

Quick links

Citations

13 review citations

Principles for modulation of the nuclear receptor superfamily.
Gronemeyer et al. (2004)
12 more

14 mentions without citation

Ligands of Therapeutic Utility for the Liver X Receptors.
Komati et al. (2017)
13 more