› 1psk

X-ray diffraction
2.8Å resolution

THE CRYSTAL STRUCTURE OF AN FAB FRAGMENT THAT BINDS TO THE MELANOMA-ASSOCIATED GD2 GANGLIOSIDE

Released:
DOI: 10.2210/pdb1psk/pdb
PDB entry 1psk coloured by chain, front view.
PDB entry 1psk coloured by chain, side view.
PDB entry 1psk coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
The crystal structure of a Fab fragment to the melanoma-associated GD2 ganglioside.
Pichla SL, Murali R, Burnett RM
J Struct Biol 119 6-16 (1997)
PMID: 9216084

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-224980 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Immunoglobulin kappa constant Chain: L
Molecule details ›
Chain: L
Length: 213 amino acids
Theoretical weight: 23.21 KDa
Source organism: Mus musculus
UniProt:
  • Canonical: P01837 (Residues: 1-107; Coverage: 100%)
Gene name: Igkc
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins
ANTIBODY Chain: H
Molecule details ›
Chain: H
Length: 209 amino acids
Theoretical weight: 22.37 KDa
Source organism: Mus musculus
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RUH2R
Spacegroup: P21
Unit cell:
a: 37.6Å b: 94.1Å c: 67.4Å
α: 90° β: 101° γ: 90°
R-values:
R R work R free
0.204 0.204 0.326

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Citations

7 review citations

Disialoganglioside GD2 as a therapeutic target for human diseases.
Suzuki et al. (2015)
6 more

4 mentions without citation

Antibody repertoire deep sequencing reveals antigen-independent selection in maturing B cells.
Kaplinsky et al. (2014)
3 more