› 1py5

X-ray diffraction
2.3Å resolution

Function and Biology Details

Reaction catalysed: 
ATP + [receptor-protein] = ADP + [receptor-protein] phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-153250 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
TGF-beta receptor type-1 Chain: A
Molecule details ›
Chain: A
Length: 326 amino acids
Theoretical weight: 37.1 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P36897 (Residues: 175-500; Coverage: 69%)
Gene names: ALK5, SKR4, TGFBR1
Sequence domains:
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand SO4 1 x SO4
Ligand PY1 1 x PY1
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: P212121
Unit cell:
a: 41.829Å b: 78.111Å c: 90.686Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.26 0.258 0.292
Expression system: Spodoptera frugiperda

Quick links

Citations

20 review citations

The polarization of immune cells in the tumour environment by TGFbeta.
Flavell et al. (2010)
19 more

19 mentions without citation

Substrate and docking interactions in serine/threonine protein kinases.
Goldsmith et al. (2007)
18 more