› 1q33

X-ray diffraction
1.81Å resolution

Crystal structure of human ADP-ribose pyrophosphatase NUDT9

Released:
DOI: 10.2210/pdb1q33/pdb
PDB entry 1q33 coloured by chain, front view.
PDB entry 1q33 coloured by chain, side view.
PDB entry 1q33 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The crystal structure and mutational analysis of human NUDT9.
Shen BW, Perraud AL, Scharenberg A, Stoddard BL
J Mol Biol 332 385-98 (2003)
PMID: 12948489

Function and Biology Details

Reaction catalysed: 
ADP-D-ribose + H(2)O = AMP + D-ribose 5-phosphate
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-189773 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
ADP-ribose pyrophosphatase, mitochondrial Chain: A
Molecule details ›
Chain: A
Length: 292 amino acids
Theoretical weight: 33.31 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9BW91 (Residues: 59-350; Coverage: 83%)
Gene names: NUDT10, NUDT9, PSEC0099, UNQ3012/PRO9771
Sequence domains: NUDIX domain
Structure domains: Nucleoside Triphosphate Pyrophosphohydrolase

Ligands and Environments

2 bound ligands:
Ligand BGC 1 x BGC
Ligand SO4 6 x SO4
1 modified residue:
Ligand MSE 5 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.2
Spacegroup: I222
Unit cell:
a: 79.837Å b: 87.497Å c: 119.814Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.204 0.201 0.231
Expression system: Escherichia coli

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Citations

22 review citations

Reactive oxygen species in inflammation and tissue injury.
Mittal et al. (2014)
21 more

18 mentions without citation

The role of neuronal complexes in human X-linked brain diseases.
Laumonnier et al. (2007)
17 more