› 1q9c

X-ray diffraction
3.21Å resolution

Crystal Structure of the Histone domain of Son of Sevenless

Released:
DOI: 10.2210/pdb1q9c/pdb
PDB entry 1q9c coloured by chain, front view.
PDB entry 1q9c coloured by chain, side view.
PDB entry 1q9c coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Tandem histone folds in the structure of the N-terminal segment of the ras activator Son of Sevenless.
Sondermann H, Soisson SM, Bar-Sagi D, Kuriyan J
Structure 11 1583-93 (2003)
PMID: 14656442

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-170560 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Son of sevenless homolog 1 Chains: A, B, C, D, E, F, G, H, I
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I
Length: 191 amino acids
Theoretical weight: 22.19 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q07889 (Residues: 1-191; Coverage: 14%)
Gene name: SOS1
Structure domains: Histone, subunit A

Ligands and Environments

No bound ligands
1 modified residue:
Ligand MSE 36 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.2.2
Spacegroup: P212121
Unit cell:
a: 93.397Å b: 109.199Å c: 212.399Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.255 0.255 0.292
Expression system: Escherichia coli

Quick links

Citations

6 review citations

The RasGrf family of mammalian guanine nucleotide exchange factors.
Fernández-Medarde et al. (2011)
5 more

7 mentions without citation

Computational docking and solution x-ray scattering predict a membrane-interacting role for the histone domain of the Ras activator son of sevenless.
Sondermann et al. (2005)
6 more