› 1qcf

X-ray diffraction
2Å resolution

CRYSTAL STRUCTURE OF HCK IN COMPLEX WITH A SRC FAMILY-SELECTIVE TYROSINE KINASE INHIBITOR

Released:
DOI: 10.2210/pdb1qcf/pdb
PDB entry 1qcf coloured by chain, front view.
PDB entry 1qcf coloured by chain, side view.
PDB entry 1qcf coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of Hck in complex with a Src family-selective tyrosine kinase inhibitor.
Schindler T, Sicheri F, Pico A, Gazit A, Levitzki A, Kuriyan J
Mol Cell 3 639-48 (1999)
PMID: 10360180

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-140247 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosine-protein kinase HCK Chain: A
Molecule details ›
Chain: A
Length: 454 amino acids
Theoretical weight: 52 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P08631 (Residues: 81-526; Coverage: 85%)
Gene name: HCK
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand PP1 1 x PP1
1 modified residue:
Ligand PTR 1 x PTR

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200
Spacegroup: P212121
Unit cell:
a: 51.015Å b: 99.002Å c: 103.387Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.215 0.215 0.257
Expression system: Not provided

Quick links

Citations

40 review citations

The conformational plasticity of protein kinases.
Huse et al. (2002)
39 more

71 mentions without citation

Catalytic control in the EGF receptor and its connection to general kinase regulatory mechanisms.
Jura et al. (2011)
70 more