Function and Biology Details
Reaction catalysed:
Strict requirement for Asp at position P1 and has a preferred cleavage sequence of (Leu/Asp/Val)-Glu-Thr-Asp-|-(Gly/Ser/Ala)
Biochemical function:
Biological process:
Cellular component:
- not assigned
Sequence domains:
Structure domain:
Structure analysis Details
Assembly composition:
hetero hexamer (preferred)
Assembly name:
Caspase-8 complex and peptide (preferred)
PDBe Complex ID:
PDB-CPX-162409 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Caspase-8 subunit p18
Molecule details ›
Chains: A, C, E, G, I, K
Length: 153 amino acids
Theoretical weight: 17.42 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: Caspase domain
Structure domains: Rossmann fold
Length: 153 amino acids
Theoretical weight: 17.42 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical:
Q14790 (Residues: 222-374; Coverage: 32%)
Sequence domains: Caspase domain
Structure domains: Rossmann fold
Caspase-8 subunit p10
Molecule details ›
Chains: B, D, F, H, J, L
Length: 88 amino acids
Theoretical weight: 10.19 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: Caspase domain
Structure domains: Caspase-like
Length: 88 amino acids
Theoretical weight: 10.19 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical: Q14790 (Residues: 390-477; Coverage: 18%)
Sequence domains: Caspase domain
Structure domains: Caspase-like
Ligands and Environments
No bound ligands
No modified residues
Experiments and Validation Details
X-ray source:
ESRF BEAMLINE BM1A
Spacegroup:
C2
Expression system: Escherichia coli
