› 1qf8

X-ray diffraction
1.74Å resolution

TRUNCATED FORM OF CASEIN KINASE II BETA SUBUNIT (2-182) FROM HOMO SAPIENS

Released:
DOI: 10.2210/pdb1qf8/pdb
PDB entry 1qf8 coloured by chain, front view.
PDB entry 1qf8 coloured by chain, side view.
PDB entry 1qf8 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of the human protein kinase CK2 regulatory subunit reveals its zinc finger-mediated dimerization.
Chantalat L, Leroy D, Filhol O, Nueda A, Benitez MJ, Chambaz EM, Cochet C, Dideberg O
EMBO J 18 2930-40 (1999)
PMID: 10357806

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-159248 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Casein kinase II subunit beta Chains: A, B
Molecule details ›
Chains: A, B
Length: 182 amino acids
Theoretical weight: 21.55 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P67870 (Residues: 1-182; Coverage: 85%)
Gene names: CK2N, CSNK2B, G5A
Sequence domains: Casein kinase II regulatory subunit
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand ZN 2 x ZN
Ligand MG 1 x MG
1 modified residue:
Ligand MSE 18 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE BM14
Spacegroup: P42212
Unit cell:
a: 132.23Å b: 132.23Å c: 63.78Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.194 0.194 0.219
Expression system: Escherichia coli

Quick links

Citations

17 review citations

Protein kinase CK2: structure, regulation and role in cellular decisions of life and death.
Litchfield DW. (2003)
16 more

6 mentions without citation

Prediction of enzyme function based on 3D templates of evolutionarily important amino acids.
Kristensen et al. (2008)
5 more