› 1qg3

X-ray diffraction
2.15Å resolution

CRYSTAL STRUCTURE OF A TANDEM PAIR OF FIBRONECTIN TYPE III DOMAINS FROM THE CYTOPLASMIC TAIL OF INTEGRIN ALPHA6 BETA4

Released:
DOI: 10.2210/pdb1qg3/pdb
PDB entry 1qg3 coloured by chain, front view.
PDB entry 1qg3 coloured by chain, side view.
PDB entry 1qg3 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of a tandem pair of fibronectin type III domains from the cytoplasmic tail of integrin alpha6beta4.
de Pereda JM, Wiche G, Liddington RC
EMBO J 18 4087-95 (1999)
PMID: 10428948

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-147644 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Integrin beta-4 Chains: A, B
Molecule details ›
Chains: A, B
Length: 195 amino acids
Theoretical weight: 21.67 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P16144 (Residues: 1126-1320; Coverage: 11%)
Gene name: ITGB4
Sequence domains: Fibronectin type III domain
Structure domains: Immunoglobulins

Ligands and Environments

2 bound ligands:
Ligand CAC 2 x CAC
Ligand SO4 3 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 14-BM-C
Spacegroup: P43212
Unit cell:
a: 59.04Å b: 59.04Å c: 246.05Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.201 0.201 0.262
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

12 review citations

Conformational regulation of integrin structure and function.
Shimaoka et al. (2002)
11 more

9 mentions without citation

Architecture of Eph receptor clusters.
Himanen et al. (2010)
8 more