› 1qiv

X-ray diffraction
2.64Å resolution

CALMODULIN COMPLEXED WITH N-(3,3,-DIPHENYLPROPYL)-N'-[1-R-(3,4-BIS-BUTOXYPHENYL)-ETHYL]-PROPYLENEDIAMINE (DPD), 1:2 COMPLEX

Released:
DOI: 10.2210/pdb1qiv/pdb
PDB entry 1qiv coloured by chain, front view.
PDB entry 1qiv coloured by chain, side view.
PDB entry 1qiv coloured by chain, top view.
Source organism: Bos taurus
Primary publication:
A new potent calmodulin antagonist with arylalkylamine structure: crystallographic, spectroscopic and functional studies.
Harmat V, Böcskei Z, Náray-Szabó G, Bata I, Csutor AS, Hermecz I, Arányi P, Szabó B, Liliom K, Vértessy BG, Ovádi J
J Mol Biol 297 747-55 (2000)
PMID: 10731425

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-158581 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Calmodulin Chain: A
Molecule details ›
Chain: A
Length: 148 amino acids
Theoretical weight: 16.72 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P62157 (Residues: 2-149; Coverage: 99%)
Gene names: CALM, CAM
Sequence domains: EF-hand domain pair
Structure domains: EF-hand

Ligands and Environments

2 bound ligands:
Ligand CA 4 x CA
Ligand DPD 2 x DPD
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RUH2R
Spacegroup: P3221
Unit cell:
a: 40.125Å b: 40.125Å c: 173.814Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.207 0.207 0.301

Quick links

Citations

22 citation in other articles

Crystal structure of a MARCKS peptide containing the calmodulin-binding domain in complex with Ca2+-calmodulin.
Yamauchi et al. (2003)
21 more

2 mentions without citation

The NMDA receptor NR1 C1 region bound to calmodulin: structural insights into functional differences between homologous domains.
Ataman et al. (2007)
1 more