› 1qk1

X-ray diffraction
2.7Å resolution

CRYSTAL STRUCTURE OF HUMAN UBIQUITOUS MITOCHONDRIAL CREATINE KINASE

Released:
DOI: 10.2210/pdb1qk1/pdb
PDB entry 1qk1 coloured by chain, front view.
PDB entry 1qk1 coloured by chain, side view.
PDB entry 1qk1 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of human ubiquitous mitochondrial creatine kinase.
Eder M, Fritz-Wolf K, Kabsch W, Wallimann T, Schlattner U
Proteins 39 216-25 (2000)
PMID: 10737943

Function and Biology Details

Reaction catalysed: 
ATP + creatine = ADP + phosphocreatine
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
homo octamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-146261 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Creatine kinase U-type, mitochondrial Chains: A, B, C, D, E, F, G, H
Molecule details ›
Chains: A, B, C, D, E, F, G, H
Length: 379 amino acids
Theoretical weight: 43.22 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P12532 (Residues: 39-417; Coverage: 91%)
Gene names: CKMT, CKMT1A, CKMT1B
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand PO4 8 x PO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ELLIOTT GX-18
Spacegroup: P21
Unit cell:
a: 91.811Å b: 125.868Å c: 212.074Å
α: 90° β: 96.71° γ: 90°
R-values:
R R work R free
0.195 0.195 0.219
Expression system: Escherichia coli BL21(DE3)

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Citations

6 review citations

The creatine kinase system and pleiotropic effects of creatine.
Wallimann et al. (2011)
5 more

15 mentions without citation

Metabolic Basis of Creatine in Health and Disease: A Bioinformatics-Assisted Review.
Bonilla et al. (2021)
14 more