› 1qlf

X-ray diffraction
2.65Å resolution

MHC CLASS I H-2DB COMPLEXED WITH GLYCOPEPTIDE K3G

Released:
DOI: 10.2210/pdb1qlf/pdb
PDB entry 1qlf coloured by chain, front view.
PDB entry 1qlf coloured by chain, side view.
PDB entry 1qlf coloured by chain, top view.
Source organisms:
Primary publication:
Crystal structures of two H-2Db/glycopeptide complexes suggest a molecular basis for CTL cross-reactivity.
Glithero A, Tormo J, Haurum JS, Arsequell G, Valencia G, Edwards J, Springer S, Townsend A, Pao YL, Wormald M, Dwek RA, Jones EY, Elliott T
Immunity 10 63-74 (1999)
PMID: 10023771

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-135284 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
H-2 class I histocompatibility antigen, D-B alpha chain Chain: A
Molecule details ›
Chain: A
Length: 276 amino acids
Theoretical weight: 32.09 KDa
Source organism: Mus musculus
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P01899 (Residues: 25-300; Coverage: 82%)
Gene name: H2-D1
Sequence domains:
Structure domains:
Beta-2-microglobulin Chain: B
Molecule details ›
Chain: B
Length: 99 amino acids
Theoretical weight: 11.75 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P61769 (Residues: 21-119; Coverage: 100%)
Gene names: B2M, CDABP0092, HDCMA22P
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins
Nucleoprotein Chain: C
Molecule details ›
Chain: C
Length: 9 amino acids
Theoretical weight: 979 Da
UniProt:
  • Canonical: P04857 (Residues: 324-332; Coverage: 2%)
Gene names: N, NP

Ligands and Environments

3 bound ligands:
Ligand GOL 2 x GOL
Ligand SO4 1 x SO4
Ligand NAG 1 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE BM14
Spacegroup: P21
Unit cell:
a: 61.073Å b: 58.272Å c: 77.146Å
α: 90° β: 108.57° γ: 90°
R-values:
R R work R free
0.204 0.204 0.267
Expression system: Cricetulus griseus

Quick links

Citations

21 review citations

The sweet and sour of cancer: glycans as novel therapeutic targets.
Fuster et al. (2005)
20 more

5 mentions without citation

Carbohydrates as T-cell antigens with implications in health and disease.
Sun et al. (2016)
4 more