Function and Biology Details
Reaction catalysed:
DNA (containing 4-O-methylthymine) + protein L-cysteine = DNA (without 4-O-methylthymine) + protein S-methyl-L-cysteine
Biochemical function:
Biological process:
Cellular component:
- not assigned
Sequence domains:
- Methylated-DNA-[protein]-cysteine S-methyltransferase, DNA binding
- Methylated-DNA-[protein]-cysteine S-methyltransferase, active site
- Methylated DNA-protein cysteine methyltransferase, DNA binding domain
- Winged helix-like DNA-binding domain superfamily
- Methylated DNA-protein cysteine methyltransferase domain superfamily
- Methylguanine DNA methyltransferase, ribonuclease-like domain
Structure analysis Details
Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-147730 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Methylated-DNA--protein-cysteine methyltransferase
Molecule details ›
Chain: A
Length: 176 amino acids
Theoretical weight: 18.95 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains:
Length: 176 amino acids
Theoretical weight: 18.95 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical:
P16455 (Residues: 1-176; Coverage: 85%)
Sequence domains:
- 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain
- 6-O-methylguanine DNA methyltransferase, DNA binding domain
Ligands and Environments
No bound ligands
No modified residues
Experiments and Validation Details
X-ray source:
SRS BEAMLINE PX9.6
Spacegroup:
P3121
Expression system: Escherichia coli
