› 1qp1

X-ray diffraction
2.06Å resolution

KAPPA VARIABLE LIGHT CHAIN

Released:
DOI: 10.2210/pdb1qp1/pdb
PDB entry 1qp1 coloured by chain, front view.
PDB entry 1qp1 coloured by chain, side view.
PDB entry 1qp1 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Molecular structure of the amyloid-forming protein kappa I Bre.
Steinrauf LK, Chiang MY, Shiuan D
J Biochem 125 422-9 (1999)
PMID: 9990143

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-134445 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Immunoglobulin kappa variable 1-33 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 107 amino acids
Theoretical weight: 11.79 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P01594 (Residues: 23-117; Coverage: 100%)
Gene name: IGKV1-33
Sequence domains: Immunoglobulin V-set domain
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU300
Spacegroup: C2221
Unit cell:
a: 143.99Å b: 82.56Å c: 77.56Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.183 0.153 0.212
Expression system: Escherichia coli

Quick links

Citations

2 review citations

Review: immunoglobulin light chain amyloidosis--the archetype of structural and pathogenic variability.
Bellotti et al. (2000)
1 more

4 mentions without citation

BSDB: the biomolecule stretching database.
Sikora et al. (2011)
3 more