› 1qpd

X-ray diffraction
2Å resolution

STRUCTURAL ANALYSIS OF THE LYMPHOCYTE-SPECIFIC KINASE LCK IN COMPLEX WITH NON-SELECTIVE AND SRC FAMILY SELECTIVE KINASE INHIBITORS

Released:
DOI: 10.2210/pdb1qpd/pdb
PDB entry 1qpd coloured by chain, front view.
PDB entry 1qpd coloured by chain, side view.
PDB entry 1qpd coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural analysis of the lymphocyte-specific kinase Lck in complex with non-selective and Src family selective kinase inhibitors.
Zhu X, Kim JL, Newcomb JR, Rose PE, Stover DR, Toledo LM, Zhao H, Morgenstern KA
Structure 7 651-61 (1999)
PMID: 10404594

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138948 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosine-protein kinase Lck Chain: A
Molecule details ›
Chain: A
Length: 279 amino acids
Theoretical weight: 32.18 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P06239 (Residues: 231-509; Coverage: 55%)
Gene name: LCK
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand SO4 1 x SO4
Ligand STU 1 x STU
1 modified residue:
Ligand PTR 1 x PTR

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X4A
Spacegroup: P212121
Unit cell:
a: 42.2Å b: 73.8Å c: 91.42Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.195 0.195 0.237
Expression system: Trichoplusia ni

Quick links

Citations

24 review citations

Protein tyrosine kinase structure and function.
Hubbard et al. (2000)
23 more

5 mentions without citation

Structure-based molecular modeling in SAR analysis and lead optimization.
Temml et al. (2021)
4 more