› 1qpl

X-ray diffraction
2.9Å resolution

FK506 BINDING PROTEIN (12 KDA, HUMAN) COMPLEX WITH L-707,587

Released:
DOI: 10.2210/pdb1qpl/pdb
PDB entry 1qpl coloured by chain, front view.
PDB entry 1qpl coloured by chain, side view.
PDB entry 1qpl coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
32-Indolyl ether derivatives of ascomycin: three-dimensional structures of complexes with FK506-binding protein.
Becker JW, Rotonda J, Cryan JG, Martin M, Parsons WH, Sinclair PJ, Wiederrecht G, Wong F
J Med Chem 42 2798-804 (1999)
PMID: 10425089

Function and Biology Details

Reaction catalysed: 
Peptidylproline (omega=180) = peptidylproline (omega=0)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-158814 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Peptidyl-prolyl cis-trans isomerase FKBP1A Chains: A, C
Molecule details ›
Chains: A, C
Length: 107 amino acids
Theoretical weight: 11.84 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P62942 (Residues: 2-108; Coverage: 99%)
Gene names: FKBP1, FKBP12, FKBP1A
Sequence domains: FKBP-type peptidyl-prolyl cis-trans isomerase
Structure domains: Chitinase A; domain 3

Ligands and Environments

1 bound ligand:
Ligand 587 2 x 587
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200
Spacegroup: I4
Unit cell:
a: 119.74Å b: 119.74Å c: 57.21Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.223 0.223 0.342
Expression system: Escherichia coli

Quick links

Citations

7 citation in other articles

Role for A kinase-anchoring proteins (AKAPS) in glutamate receptor trafficking and long term synaptic depression.
Snyder et al. (2005)
6 more