› 1qse

X-ray diffraction
2.8Å resolution

STRUCTURE OF HUMAN A6-TCR BOUND TO HLA-A2 COMPLEXED WITH ALTERED HTLV-1 TAX PEPTIDE V7R

Released:
DOI: 10.2210/pdb1qse/pdb
PDB entry 1qse coloured by chain, front view.
PDB entry 1qse coloured by chain, side view.
PDB entry 1qse coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Four A6-TCR/peptide/HLA-A2 structures that generate very different T cell signals are nearly identical.
Ding YH, Baker BM, Garboczi DN, Biddison WE, Wiley DC
Immunity 11 45-56 (1999)
PMID: 10435578

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
hetero pentamer (preferred)
PDBe Complex ID:
PDB-CPX-209033 (preferred)
Entry contents:
5 distinct polypeptide molecules
Macromolecules (5 distinct):
HLA class I histocompatibility antigen, A alpha chain Chain: A
Molecule details ›
Chain: A
Length: 274 amino acids
Theoretical weight: 31.73 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P04439 (Residues: 25-298; Coverage: 80%)
Gene names: HLA-A, HLAA
Sequence domains:
Structure domains:
Beta-2-microglobulin Chain: B
Molecule details ›
Chain: B
Length: 100 amino acids
Theoretical weight: 11.88 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P61769 (Residues: 20-119; Coverage: 100%)
Gene names: B2M, CDABP0092, HDCMA22P
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins
Tax Peptide V7R Chain: C
Molecule details ›
Chain: C
Length: 9 amino acids
Theoretical weight: 1.13 KDa
PROTEIN (human T-Cell receptor) Chain: D
Molecule details ›
Chain: D
Length: 200 amino acids
Theoretical weight: 22.09 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
Structure domains: Immunoglobulins
PROTEIN (human T-Cell receptor) Chain: E
Molecule details ›
Chain: E
Length: 243 amino acids
Theoretical weight: 27.18 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ELLIOTT GX-13
Spacegroup: C2
Unit cell:
a: 224.862Å b: 48.891Å c: 94.456Å
α: 90° β: 90.49° γ: 90°
R-values:
R R work R free
0.243 0.243 0.29
Expression system: Escherichia coli

Quick links

Citations

70 review citations

How TCRs bind MHCs, peptides, and coreceptors.
Rudolph et al. (2006)
69 more

16 mentions without citation

The structural basis of αβ T-lineage immune recognition: TCR docking topologies, mechanotransduction, and co-receptor function.
Wang et al. (2012)
15 more