› 1qzu

X-ray diffraction
2.91Å resolution

crystal structure of human phosphopantothenoylcysteine decarboxylase

Released:
DOI: 10.2210/pdb1qzu/pdb
PDB entry 1qzu coloured by chain, front view.
PDB entry 1qzu coloured by chain, side view.
PDB entry 1qzu coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Unusual space-group pseudosymmetry in crystals of human phosphopantothenoylcysteine decarboxylase.
Manoj N, Ealick SE
Acta Crystallogr D Biol Crystallogr 59 1762-6 (2003)
PMID: 14501115

Function and Biology Details

Reaction catalysed: 
N-((R)-4'-phosphopantothenoyl)-L-cysteine = pantotheine 4'-phosphate + CO(2)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assemblies composition:
homo trimer
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-188409 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Phosphopantothenoylcysteine decarboxylase Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 206 amino acids
Theoretical weight: 22.57 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q96CD2 (Residues: 1-204; Coverage: 100%)
Gene names: COAC, MDS018, PPCDC, UNQ9365/PRO34154
Sequence domains: Flavoprotein
Structure domains: Flavin prenyltransferase-like

Ligands and Environments


Cofactor: Ligand FMN 4 x FMN
No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 8-BM
Spacegroup: R3
Unit cell:
a: 124.78Å b: 124.78Å c: 153.5Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.299 0.293 0.342
Expression system: Escherichia coli

Quick links

Citations

4 review citations

Vitamin in the Crosshairs: Targeting Pantothenate and Coenzyme A Biosynthesis for New Antituberculosis Agents.
Butman et al. (2020)
3 more

3 mentions without citation

The human flavoproteome.
Lienhart et al. (2013)
2 more