› 1r5k

X-ray diffraction
2.7Å resolution

Human Estrogen Receptor alpha Ligand-Binding Domain In Complex With GW5638

Released:
DOI: 10.2210/pdb1r5k/pdb
PDB entry 1r5k coloured by chain, front view.
PDB entry 1r5k coloured by chain, side view.
PDB entry 1r5k coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for an unexpected mode of SERM-mediated ER antagonism.
Wu YL, Yang X, Ren Z, McDonnell DP, Norris JD, Willson TM, Greene GL
Mol Cell 18 413-24 (2005)
PMID: 15893725

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136919 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Estrogen receptor Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 261 amino acids
Theoretical weight: 29.85 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P03372 (Residues: 297-554; Coverage: 43%)
Gene names: ESR, ESR1, NR3A1
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

1 bound ligand:
Ligand GW5 3 x GW5
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 14-BM-C
Spacegroup: P6122
Unit cell:
a: 136.031Å b: 136.031Å c: 357.626Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.208 0.205 0.236
Expression system: Escherichia coli

Quick links

Citations

44 review citations

Estrogen receptors: how do they signal and what are their targets.
Heldring et al. (2007)
43 more

25 mentions without citation

Versatility or promiscuity: the estrogen receptors, control of ligand selectivity and an update on subtype selective ligands.
Ng et al. (2014)
24 more