› 1r7r

X-ray diffraction
3.6Å resolution

The crystal structure of murine p97/VCP at 3.6A

Released:
DOI: 10.2210/pdb1r7r/pdb
PDB entry 1r7r coloured by chain, front view.
PDB entry 1r7r coloured by chain, side view.
PDB entry 1r7r coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
The crystal structure of murine p97/VCP at 3.6A.
Huyton T, Pye VE, Briggs LC, Flynn TC, Beuron F, Kondo H, Ma J, Zhang X, Freemont PS
J Struct Biol 144 337-48 (2003)
PMID: 14643202

Function and Biology Details

Reaction catalysed: 
ATP + H(2)O = ADP + phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
homo hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-169640 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transitional endoplasmic reticulum ATPase Chain: A
Molecule details ›
Chain: A
Length: 816 amino acids
Theoretical weight: 90.64 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q01853 (Residues: 1-806; Coverage: 100%)
Gene name: Vcp
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand ADP 1 x ADP
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-4
Spacegroup: P622
Unit cell:
a: 145.2Å b: 145.2Å c: 167.4Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.327 0.327 0.358
Expression system: Escherichia coli

Quick links

Citations

30 review citations

Evolutionary relationships and structural mechanisms of AAA+ proteins.
Erzberger et al. (2006)
29 more

22 mentions without citation

Structure and function of the AAA+ ATPase p97/Cdc48p.
Xia et al. (2016)
21 more