› 1rh2

X-ray diffraction
2.9Å resolution

RECOMBINANT HUMAN INTERFERON-ALPHA 2B

Released:
DOI: 10.2210/pdb1rh2/pdb
PDB entry 1rh2 coloured by chain, front view.
PDB entry 1rh2 coloured by chain, side view.
PDB entry 1rh2 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Zinc mediated dimer of human interferon-alpha 2b revealed by X-ray crystallography.
Radhakrishnan R, Walter LJ, Hruza A, Reichert P, Trotta PP, Nagabhushan TL, Walter MR
Structure 4 1453-63 (1996)
PMID: 8994971

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-134391 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Interferon alpha-2 Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 165 amino acids
Theoretical weight: 19.28 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P01563 (Residues: 24-188; Coverage: 100%)
Gene names: IFNA2, IFNA2A, IFNA2B, IFNA2C
Sequence domains: Interferon alpha/beta domain

Ligands and Environments

1 bound ligand:
Ligand ZN 4 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RUH2R
Spacegroup: P21
Unit cell:
a: 62.4Å b: 75.5Å c: 148.2Å
α: 90° β: 90.8° γ: 90°
R-values:
R R work R free
0.227 0.227 0.311
Expression system: Escherichia coli

Quick links

Citations

28 review citations

Interferons, interferon-like cytokines, and their receptors.
Pestka et al. (2004)
27 more

8 mentions without citation

Approved Antiviral Drugs over the Past 50 Years.
De Clercq et al. (2016)
7 more