› 1rja

Solution NMR

Solution Structure and Backbone Dynamics of the Nonreceptor Tyrosine Kinase PTK6/Brk SH2 Domain

Released:
DOI: 10.2210/pdb1rja/pdb
PDB entry 1rja coloured by chain, ensemble of 21 models, front view.
PDB entry 1rja coloured by chain, ensemble of 21 models, side view.
PDB entry 1rja coloured by chain, ensemble of 21 models, top view.
Source organism: Homo sapiens
Primary publication:
Solution structure and backbone dynamics of the non-receptor protein-tyrosine kinase-6 Src homology 2 domain.
Hong E, Shin J, Kim HI, Lee ST, Lee W
J Biol Chem 279 29700-8 (2004)
PMID: 15056653

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171829 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein-tyrosine kinase 6 Chain: A
Molecule details ›
Chain: A
Length: 100 amino acids
Theoretical weight: 11.36 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q13882 (Residues: 75-174; Coverage: 22%)
Gene names: BRK, PTK6
Sequence domains: SH2 domain
Structure domains: SH2 domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: distance geometry, simulated annealing
Expression system: Escherichia coli

Quick links

Citations

6 review citations

Building a better understanding of the intracellular tyrosine kinase PTK6 - BRK by BRK.
Brauer et al. (2010)
5 more

2 mentions without citation

Identification of Host Cellular Protein Substrates of SARS-COV-2 Main Protease.
Miczi et al. (2020)
1 more