› 1rkb

X-ray diffraction
2Å resolution

The structure of adrenal gland protein AD-004

Released:
DOI: 10.2210/pdb1rkb/pdb
PDB entry 1rkb coloured by chain, front view.
PDB entry 1rkb coloured by chain, side view.
PDB entry 1rkb coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The crystal structure of human adenylate kinase 6: An adenylate kinase localized to the cell nucleus.
Ren H, Wang L, Bennett M, Liang Y, Zheng X, Lu F, Li L, Nan J, Luo M, Eriksson S, Zhang C, Su XD
Proc Natl Acad Sci U S A 102 303-8 (2005)
PMID: 15630091

Function and Biology Details

Reaction catalysed: 
ATP + AMP = 2 ADP
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-195201 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Adenylate kinase isoenzyme 6 Chain: A
Molecule details ›
Chain: A
Length: 173 amino acids
Theoretical weight: 20.2 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9Y3D8 (Residues: 1-172; Coverage: 100%)
Gene names: AD-004, AK6, CGI-137, CINAP
Sequence domains: AAA domain
Structure domains: P-loop containing nucleotide triphosphate hydrolases

Ligands and Environments

2 bound ligands:
Ligand SO4 5 x SO4
Ligand LI 3 x LI
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ENRAF-NONIUS FR591
Spacegroup: P61
Unit cell:
a: 99.555Å b: 99.555Å c: 57.191Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.203 0.203 0.218
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

7 review citations

Adenylate kinase and AMP signaling networks: metabolic monitoring, signal communication and body energy sensing.
Dzeja et al. (2009)
6 more

3 mentions without citation

The crystal structure of human adenylate kinase 6: An adenylate kinase localized to the cell nucleus.
Ren et al. (2005)
2 more