› 1rl1

Solution NMR

Solution structure of human Sgt1 CS domain

Released:
DOI: 10.2210/pdb1rl1/pdb
PDB entry 1rl1 coloured by chain, ensemble of 20 models, front view.
PDB entry 1rl1 coloured by chain, ensemble of 20 models, side view.
PDB entry 1rl1 coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Human Sgt1 binds HSP90 through the CHORD-Sgt1 domain and not the tetratricopeptide repeat domain.
Lee YT, Jacob J, Michowski W, Nowotny M, Kuznicki J, Chazin WJ
J Biol Chem 279 16511-7 (2004)
PMID: 14761955

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-195174 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein SGT1 homolog Chain: A
Molecule details ›
Chain: A
Length: 114 amino acids
Theoretical weight: 13.12 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9Y2Z0 (Residues: 167-276; Coverage: 30%)
Gene name: SUGT1
Sequence domains: CS domain
Structure domains: Immunoglobulin-like

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: Distance Geometry and restrained Molecular Dynamics
Expression system: Escherichia coli

Quick links

Citations

15 review citations

Structure and mechanism of the Hsp90 molecular chaperone machinery.
Pearl et al. (2006)
14 more

16 mentions without citation

Structural Basis of IL-1 Family Cytokine Signaling.
Fields et al. (2019)
15 more