› 1rne

X-ray diffraction
2.4Å resolution

THE CRYSTAL STRUCTURE OF RECOMBINANT GLYCOSYLATED HUMAN RENIN ALONE AND IN COMPLEX WITH A TRANSITION STATE ANALOG INHIBITOR

Released:
DOI: 10.2210/pdb1rne/pdb
PDB entry 1rne coloured by chain, front view.
PDB entry 1rne coloured by chain, side view.
PDB entry 1rne coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The crystal structures of recombinant glycosylated human renin alone and in complex with a transition state analog inhibitor.
Rahuel J, Priestle JP, Grütter MG
J Struct Biol 107 227-36 (1991)
PMID: 1807356

Function and Biology Details

Reaction catalysed: 
Cleavage of Leu-|- bond in angiotensinogen to generate angiotensin I.
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-133568 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Renin Chain: A
Molecule details ›
Chain: A
Length: 340 amino acids
Theoretical weight: 37.27 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P00797 (Residues: 67-406; Coverage: 89%)
Gene name: REN
Sequence domains: Eukaryotic aspartyl protease
Structure domains: Acid Proteases

Ligands and Environments

2 bound ligands:
Ligand NAG 1 x NAG
Ligand C60 1 x C60
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P41212
Unit cell:
a: 90.9Å b: 90.9Å c: 109.4Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.176 not available not available
Expression system: Not provided

Quick links

Citations

13 review citations

Implications of protein flexibility for drug discovery.
Teague SJ. (2003)
12 more

11 mentions without citation

Pepsin-like aspartic proteases (PAPs) as model systems for combining biomolecular simulation with biophysical experiments.
Bhakat S. (2021)
10 more