› 1rod

Solution NMR

CHIMERIC PROTEIN OF INTERLEUKIN 8 AND HUMAN MELANOMA GROWTH STIMULATING ACTIVITY PROTEIN, NMR

Released:
DOI: 10.2210/pdb1rod/pdb
PDB entry 1rod coloured by chain, ensemble of 8 models, front view.
PDB entry 1rod coloured by chain, ensemble of 8 models, side view.
PDB entry 1rod coloured by chain, ensemble of 8 models, top view.
Source organism: Homo sapiens
Primary publication:
Structure and activity of a chimeric interleukin-8-melanoma-growth-stimulatory-activity protein.
Sticht H, Auer M, Schmitt B, Besemer J, Horcher M, Kirsch T, Lindley IJ, Rösch P
Eur J Biochem 235 26-35 (1996)
PMID: 8631339

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145181 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
IL-8(9-77) Chains: A, B
Molecule details ›
Chains: A, B
Length: 72 amino acids
Theoretical weight: 8.16 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P10145 (Residues: 28-93; Coverage: 84%)
Gene names: CXCL8, IL8
Sequence domains: Small cytokines (intecrine/chemokine), interleukin-8 like
Structure domains: OB fold (Dihydrolipoamide Acetyltransferase, E2P)

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Expression system: Escherichia coli

Quick links

Citations

2 citation in other articles

NMR mapping of RANTES surfaces interacting with CCR5 using linked extracellular domains.
Schnur et al. (2013)
1 more

1 mention without citation

A Closer Look at Dexamethasone and the SARS-CoV-2-Induced Cytokine Storm: In Silico Insights of the First Life-Saving COVID-19 Drug.
Morgan et al. (2021)