› 1rpq

X-ray diffraction
3Å resolution

High Affinity IgE Receptor (alpha chain) Complexed with Tight-Binding E131 'zeta' Peptide from Phage Display

Released:
DOI: 10.2210/pdb1rpq/pdb
PDB entry 1rpq coloured by chain, front view.
PDB entry 1rpq coloured by chain, side view.
PDB entry 1rpq coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Convergent recognition of the IgE binding site on the high-affinity IgE receptor.
Stamos J, Eigenbrot C, Nakamura GR, Reynolds ME, Yin J, Lowman HB, Fairbrother WJ, Starovasnik MA
Structure 12 1289-301 (2004)
PMID: 15242605

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assemblies composition:
hetero dimer
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-146142 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (6 distinct):
High affinity immunoglobulin epsilon receptor subunit alpha Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 176 amino acids
Theoretical weight: 20.46 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P12319 (Residues: 26-201; Coverage: 76%)
Gene names: FCE1A, FCER1A
Sequence domains:
Structure domains: Immunoglobulins
Peptide E131 Chains: W, X, Y, Z
Molecule details ›
Chains: W, X, Y, Z
Length: 21 amino acids
Theoretical weight: 2.54 KDa
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, BMA
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, BMA
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
3 bound ligands:
Ligand NAG 4 x NAG
Ligand SO4 2 x SO4
Ligand CIT 2 x CIT
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL9-2
Spacegroup: C2221
Unit cell:
a: 199.7Å b: 149.7Å c: 104.1Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.296 0.294 0.349
Expression systems:
  • Spodoptera frugiperda
  • Not provided

Quick links

Citations

6 review citations

IgE and mast cells in allergic disease.
Galli et al. (2012)
5 more