Function and Biology Details
Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domains:
Structure analysis Details
Assembly composition:
hetero hexamer (preferred)
PDBe Complex ID:
PDB-CPX-138943 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Insulin receptor subunit beta
Molecule details ›
Chains: A, B
Length: 306 amino acids
Theoretical weight: 35.03 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:
Length: 306 amino acids
Theoretical weight: 35.03 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
- Canonical:
P06213 (Residues: 1005-1310; Coverage: 23%)
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:
SH2B adapter protein 2
Molecule details ›
Chains: C, D
Length: 114 amino acids
Theoretical weight: 12.89 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
Sequence domains: SH2 domain
Structure domains: SH2 domain
Length: 114 amino acids
Theoretical weight: 12.89 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
- Canonical: Q9Z200 (Residues: 401-510; Coverage: 18%)
Sequence domains: SH2 domain
Structure domains: SH2 domain
