› 1s2h

Solution NMR

The Mad2 spindle checkpoint protein possesses two distinct natively folded states

Released:
DOI: 10.2210/pdb1s2h/pdb
PDB entry 1s2h coloured by chain, front view.
PDB entry 1s2h coloured by chain, side view.
PDB entry 1s2h coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The Mad2 spindle checkpoint protein has two distinct natively folded states.
Luo X, Tang Z, Xia G, Wassmann K, Matsumoto T, Rizo J, Yu H
Nat Struct Mol Biol 11 338-45 (2004)
PMID: 15024386

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171619 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mitotic spindle assembly checkpoint protein MAD2A Chain: A
Molecule details ›
Chain: A
Length: 206 amino acids
Theoretical weight: 23.5 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q13257 (Residues: 1-205; Coverage: 100%)
Gene names: MAD2, MAD2L1
Sequence domains: HORMA domain
Structure domains: HORMA domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: torsion angle dynamics
Expression system: Escherichia coli

Quick links

Citations

44 review citations

The spindle-assembly checkpoint in space and time.
Musacchio et al. (2007)
43 more

14 mentions without citation

Protein metamorphosis: the two-state behavior of Mad2.
Luo et al. (2008)
13 more