› 1s7a

Solution NMR

NMR structure of the La motif of human La protein

Released:
DOI: 10.2210/pdb1s7a/pdb
PDB entry 1s7a coloured by chain, ensemble of 20 models, front view.
PDB entry 1s7a coloured by chain, ensemble of 20 models, side view.
PDB entry 1s7a coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Structural analysis of cooperative RNA binding by the La motif and central RRM domain of human La protein.
Alfano C, Sanfelice D, Babon J, Kelly G, Jacks A, Curry S, Conte MR
Nat Struct Mol Biol 11 323-9 (2004)
PMID: 15004549

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138679 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Lupus La protein Chain: A
Molecule details ›
Chain: A
Length: 103 amino acids
Theoretical weight: 12.02 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P05455 (Residues: 1-103; Coverage: 25%)
Gene name: SSB
Sequence domains: La domain
Structure domains: Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: torsion angle dynamics
Expression system: Escherichia coli

Quick links

Citations

21 review citations

The many faces of the helix-turn-helix domain: transcription regulation and beyond.
Aravind et al. (2005)
20 more

8 mentions without citation

Controversies around the function of LARP1.
Berman et al. (2021)
7 more