› 1sav

X-ray diffraction
2.5Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-140372 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Annexin A5 Chain: A
Molecule details ›
Chain: A
Length: 320 amino acids
Theoretical weight: 36.07 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P08758 (Residues: 1-320; Coverage: 100%)
Gene names: ANX5, ANXA5, ENX2, PP4
Sequence domains: Annexin
Structure domains: Annexin

Ligands and Environments

1 bound ligand:
Ligand CA 5 x CA
1 modified residue:
Ligand PRS 5 x PRS

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RUH2R
Spacegroup: R3
Unit cell:
a: 99.6Å b: 99.6Å c: 97.04Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.186 0.186 0.259
Expression system: Escherichia coli

Quick links

Citations

22 review citations

Annexins: linking Ca2+ signalling to membrane dynamics.
Gerke et al. (2005)
21 more

1 mention without citation

Broad substrate tolerance of tubulin tyrosine ligase enables one-step site-specific enzymatic protein labeling.
Schumacher et al. (2017)