› 1sbx

X-ray diffraction
1.65Å resolution

Crystal structure of the Dachshund-homology domain of human SKI

Released:
DOI: 10.2210/pdb1sbx/pdb
PDB entry 1sbx coloured by chain, front view.
PDB entry 1sbx coloured by chain, side view.
PDB entry 1sbx coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of the dachshund homology domain of human SKI.
Wilson JJ, Malakhova M, Zhang R, Joachimiak A, Hegde RS
Structure 12 785-92 (2004)
PMID: 15130471

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-146308 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ski oncogene Chain: A
Molecule details ›
Chain: A
Length: 106 amino acids
Theoretical weight: 11.87 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P12755 (Residues: 90-192; Coverage: 14%)
Gene name: SKI
Sequence domains: SKI/SNO/DAC family
Structure domains: Ski

Ligands and Environments

No bound ligands
1 modified residue:
Ligand MSE 3 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P21
Unit cell:
a: 25.927Å b: 46.633Å c: 35.729Å
α: 90° β: 93.97° γ: 90°
R-values:
R R work R free
0.184 0.17 0.206
Expression system: Escherichia coli

Quick links

Citations

8 review citations

Ski and SnoN, potent negative regulators of TGF-beta signaling.
Deheuninck et al. (2009)
7 more

7 mentions without citation

Structural and functional characterization of a cell cycle associated HDAC1/2 complex reveals the structural basis for complex assembly and nucleosome targeting.
Itoh et al. (2015)
6 more