› 1seb

X-ray diffraction
2.7Å resolution

COMPLEX OF THE HUMAN MHC CLASS II GLYCOPROTEIN HLA-DR1 AND THE BACTERIAL SUPERANTIGEN SEB

Released:
DOI: 10.2210/pdb1seb/pdb
PDB entry 1seb coloured by chain, front view.
PDB entry 1seb coloured by chain, side view.
PDB entry 1seb coloured by chain, top view.
Source organisms:
Primary publication:
Three-dimensional structure of a human class II histocompatibility molecule complexed with superantigen.
Jardetzky TS, Brown JH, Gorga JC, Stern LJ, Urban RG, Chi YI, Stauffacher C, Strominger JL, Wiley DC
Nature 368 711-8 (1994)
PMID: 8152483

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
hetero octamer (preferred)
PDBe Complex ID:
PDB-CPX-134376 (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (4 distinct):
HLA class II histocompatibility antigen, DR alpha chain Chains: A, E
Molecule details ›
Chains: A, E
Length: 181 amino acids
Theoretical weight: 21.08 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P01903 (Residues: 26-206; Coverage: 79%)
Gene names: HLA-DRA, HLA-DRA1
Sequence domains:
Structure domains:
HLA class II histocompatibility antigen, DRB1 beta chain Chains: B, F
Molecule details ›
Chains: B, F
Length: 192 amino acids
Theoretical weight: 22.32 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P01911 (Residues: 30-221; Coverage: 81%)
Gene name: HLA-DRB1
Sequence domains:
Structure domains:
ENDOGENOUS PEPTIDE MODEL, POLY-ALA Chains: C, G
Molecule details ›
Chains: C, G
Length: 13 amino acids
Theoretical weight: 1.12 KDa
Source organism: Homo sapiens
Enterotoxin type B Chains: D, H
Molecule details ›
Chains: D, H
Length: 234 amino acids
Theoretical weight: 27.79 KDa
Source organism: Staphylococcus aureus
UniProt:
  • Canonical: P01552 (Residues: 29-262; Coverage: 98%)
Gene name: entB
Sequence domains:
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CHESS BEAMLINE F1
Spacegroup: P212121
Unit cell:
a: 95Å b: 114.7Å c: 149.8Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.257 0.257 0.327
Expression system: Homo sapiens

Quick links

Citations

103 review citations

Exotoxins of Staphylococcus aureus.
Dinges et al. (2000)
102 more

13 mentions without citation

The evolving field of biodefence: therapeutic developments and diagnostics.
Burnett et al. (2005)
12 more