› 1sg4

X-ray diffraction
1.3Å resolution

Crystal structure of human mitochondrial delta3-delta2-enoyl-CoA isomerase

Released:
DOI: 10.2210/pdb1sg4/pdb
PDB entry 1sg4 coloured by chain, front view.
PDB entry 1sg4 coloured by chain, side view.
PDB entry 1sg4 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The 1.3 A crystal structure of human mitochondrial Delta3-Delta2-enoyl-CoA isomerase shows a novel mode of binding for the fatty acyl group.
Partanen ST, Novikov DK, Popov AN, Mursula AM, Hiltunen JK, Wierenga RK
J. Mol. Biol. 342 1197-208 (2004)
PMID: 15351645

Function and Biology Details

Reaction catalysed: 
A (3E)-alk-3-enoyl-CoA = a (2E)-alk-2-enoyl-CoA
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assemblies composition:
homo trimer (preferred)
homo hexamer
Assembly name:
PDBe Complex ID:
PDB-CPX-154496 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Enoyl-CoA delta isomerase 1, mitochondrial Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 260 amino acids
Theoretical weight: 28.62 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P42126 (Residues: 43-302; Coverage: 86%)
Gene names: DCI, ECI1
Sequence domains: Enoyl-CoA hydratase/isomerase
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand CO8 1 x CO8
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: EMBL/DESY, HAMBURG BEAMLINE X13
Spacegroup: C2
Unit cell:
a: 100.984Å b: 78.288Å c: 113.209Å
α: 90° β: 116.39° γ: 90°
R-values:
R R work R free
0.157 0.157 0.202
Expression system: Escherichia coli

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Citations

3 review citations

Peroxisomal beta-oxidation--a metabolic pathway with multiple functions.
Poirier et al. (2006)
2 more

6 mentions without citation

Using sequence similarity networks for visualization of relationships across diverse protein superfamilies.
Atkinson et al. (2009)
5 more