› 1shd

X-ray diffraction
2Å resolution

PEPTIDE INHIBITORS OF SRC SH3-SH2-PHOSPHOPROTEIN INTERACTIONS

Released:
DOI: 10.2210/pdb1shd/pdb
PDB entry 1shd coloured by chain, front view.
PDB entry 1shd coloured by chain, side view.
PDB entry 1shd coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Peptide inhibitors of src SH3-SH2-phosphoprotein interactions.
Gilmer T, Rodriguez M, Jordan S, Crosby R, Alligood K, Green M, Kimery M, Wagner C, Kinder D, Charifson P
J Biol Chem 269 31711-9 (1994)
PMID: 7527393

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-146385 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Proto-oncogene tyrosine-protein kinase Src Chain: A
Molecule details ›
Chain: A
Length: 107 amino acids
Theoretical weight: 12.3 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P12931 (Residues: 144-249; Coverage: 20%)
Gene names: SRC, SRC1
Sequence domains: SH2 domain
Structure domains: SH2 domain
TRKA RECEPTOR Chain: B
Molecule details ›
Chain: B
Length: 6 amino acids
Theoretical weight: 788 Da
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

No bound ligands
1 modified residue:
Ligand PTR 1 x PTR

Experiments and Validation Details

Entry percentile scores
Spacegroup: P212121
Unit cell:
a: 41.5Å b: 44.9Å c: 75.6Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.192 0.192 not available
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

13 review citations

Modular peptide recognition domains in eukaryotic signaling.
Kuriyan et al. (1997)
12 more

6 mentions without citation

How Structural Biologists and the Protein Data Bank Contributed to Recent FDA New Drug Approvals.
Westbrook et al. (2019)
5 more